FROM MEDICINAL PLANT TO NOXIOUS WEED: BRYONIA ALBA L. (CUCURBITACEAE) IN NORTHERN AND EASTERN EUROPE


Predicting the Effects of CYP2C19 and Carboxylesterases on Vicagrel, a Novel P2Y12 Antagonist, by Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach

Vicagrel, a novel acetate derivative of clopidogrel, chiggate.com exhibits a favorable safety profile and excellent antiplatelet activity.Studies aim at identifying genetic and non-genetic factors affecting vicagrel metabolic enzymes Cytochrome P450 2C19 (CYP2C19), Carboxylesterase (CES) 1 and 2 (CES1 and CES2), which may potentially lead to altere

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